936464

3-(3-Fluoro-4-piperidin-4-ylphenylamino)piperidine-2,6-dione hydrochloride

≥95%

• Sinônimo(s): 2,6-Piperidinedione, 3-[[3-fluoro-4-(4-piperidinyl)phenyl]amino]-, hydrochloride
• Fórmula empírica (Notação de Hill): C₁₆H₂₀FN₃O₂ · xHCl
• Número CAS: 2654822-04-3
• Peso molecular: 305.35 (free base basis)
• Código UNSPSC: 12161600
• NACRES: NA.22

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95%
• Formulário: powder or crystals
• cor: off-white to beige
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.O=C1NC(=O)C(NC2=CC=C(C(F)=C2)C3CCNCC3)CC1
• InChI: 1S/C16H20FN3O2.ClH/c17-13-9-11(19-14-3-4-15(21)20-16(14)22)1-2-12(13)10-5-7-18-8-6-10;/h1-2,9-10,14,18-19H,3-8H2,(H,20,21,22);1H
• chave InChI: VJQKECGXGMCYHY-UHFFFAOYSA-N

Descrição

Aplicação

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachment via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

targeted protein degradation
When used with other protein degrader building blocks
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Outras notas

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable