920533

2-(2-((1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl)-1H-imidazol-1-yl)acetic acid

• Sinônimo(s): Rigid linker for PROTAC^® development
• Fórmula empírica (Notação de Hill): C₁₆H₂₅N₃O₄
• Peso molecular: 323.39
• Número MDL: MFCD34602225
• Código UNSPSC: 12352106
• NACRES: NA.22

Propriedades

• Formulário: powder or crystals
• Nível de qualidade: 100
• adequação da reação: reagent type: linker
• grupo funcional: Boc; carboxylic acid
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC(C)(OC(N1CCC(CC1)CC2=NC=CN2CC(O)=O)=O)C
• InChI: 1S/C16H25N3O4/c1-16(2,3)23-15(22)18-7-4-12(5-8-18)10-13-17-6-9-19(13)11-14(20)21/h6,9,12H,4-5,7-8,10-11H2,1-3H3,(H,20,21)
• chave InChI: ZEGRCDXGLVGVNE-UHFFFAOYSA-N

Descrição

Aplicação

2-(2-((1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl)-1H-imidazol-1-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920649
920665
920673
920703

Outras notas

Portal:Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable