914223

Biotin-SLF

• Sinônimo(s): (R)-3-(3,4-Dimethoxyphenyl)-1-(3-(4,18-dioxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-8,11,14-trioxa-5,17-diazadocosanamido)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate, Bio-SLF, Biotin-conjugated FKBP12WT-directed ligand, Biotin-conjugated SLF ligand, FKBP12WT affinity probe for PROTAC^® and targeted protein degradation research
• Fórmula empírica (Notação de Hill): C₅₂H₇₆N₆O₁₃S
• Número CAS: 2230857-85-7
• Peso molecular: 1025.26
• NACRES: NA.22

Propriedades

• ligand: biotin
• Nível de qualidade: 100
• forma: powder
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(CCC(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)=O)NC3=CC([C@H](OC([C@@H]4CCCCN4C(C(C(C)(C)CC)=O)=O)=O)CCC5=CC=C(OC)C(OC)=C5)=CC=C3

Descrição

Aplicação

Biotin-SLF (bio-SLF) is an FKBP12^WT affinity probe useful in chemical biology or targeted protein degradation where FKBP12 is used as a tool protein and its enrichment is required in discovery experiments or assay validation.


Related tools:
Additional bifunctional tools for FKPB12 variants:

• dTAG-13 (SML2601) for FKBP12^F36V; and KB02-SLF (914738), KB03-SLF (914975), and KB04-SLF (913715) for FKBP12WT
• Cereblon (CRBN) affinity probe: Biotin-Thalidomide (913979)

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Outras notas

The dTAG system for immediate and target-specific protein degradation

Technology Spotlight: Building PROTAC^® Degraders for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable