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901841

Sigma-Aldrich

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average Mn 5,000, PCL average Mn 5,000

Sinônimo(s):

NHS ester PEG-PCL diblock copolymer, NHS ester-PEG-PCL, PEG-b-PCL, PEG-PCL

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About This Item

Fórmula linear:
C10H14NO5S[C2H4O]n[C6H10O2]mH
Código UNSPSC:
12352005
NACRES:
NA.23

Formulário

powder or solid

peso molecular

PCL average Mn 5,000
PEG average Mn 5,000

cor

white to off-white

PDI

≤1.3 (by GPC)

temperatura de armazenamento

−20°C

Categorias relacionadas

Aplicação

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The NHS ester functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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