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900657

Sigma-Aldrich

Methoxy poly(ethylene glycol)-b-poly(D,L-lactide)

2k-5k

Sinônimo(s):

mPEG-b-PLA, mPEG-PLA

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About This Item

Fórmula linear:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
Código UNSPSC:
12162002
NACRES:
NA.23

Nível de qualidade

100

forma

powder or chunks

peso molecular

PDLLA average Mn ~5,000
PEG average Mn ~2,000

temperatura de armazenamento

2-8°C

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Aplicação

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(D,L-lactide) (PLA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCN5857
MKCD0525

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Yuan Zhang et al.
Pharmaceutical research, 28(5), 1167-1178 (2011-02-23)
Somatostatin analogue octreotide (OCT)-modified PEG-b-PLA micelles were constructed to bind to somatostatin receptors (SSTRs) overexpressed on tumor cells for enhanced intracellular drug delivery and improved therapeutic efficacy for malignant tumors. Copolymers conjugated with octreotide (OCT-PEG₆₀₀₀-b-PLA₅₀₀₀) were synthesized. The fluorescent probe
Yiguang Wang et al.
Pharmaceutical research, 27(9), 1861-1868 (2010-06-19)
To develop an efficient tumor vasculature-targeted polymeric micelle delivery system for combretastatin A4 (CA4), a novel antivascular agent. CA4-loaded micelles were prepared from poly (ethylene glycol)-b-poly (d, l-lactide) copolymers. RGD peptides that target integrins alphavbeta3 and alphavbeta5, markers of angiogenic
Ho-Chul Shin et al.
Journal of controlled release : official journal of the Controlled Release Society, 140(3), 294-300 (2009-05-05)
Current clinical and preclinical anticancer formulations are limited by their use of toxic excipients and stability issues upon combining different drug formulations. We have found that poly(ethylene glycol)-block-poly(d,l lactic acid) (PEG-b-PLA) micelles can deliver multiple poorly water-soluble drugs at clinically
Zahra Daman et al.
Pharmaceutical research, 32(11), 3756-3767 (2015-08-01)
Resistance to gemcitabine in pancreatic cancer (PC) may account for the failure of conventional treatments. Recently, salinomycin (SAL) has been identified as selective inhibitor of cancer stem cells (CSCs). In our study, we aimed to deliver SAL to gemcitabine-resistant PC

Artigos

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

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