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765139

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA Mn 7,000

Sinônimo(s):

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA

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About This Item

Fórmula linear:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
Código UNSPSC:
12162002
NACRES:
NA.23

Formulário

solid

proporção de alimentação

lactide:glycolide 50:50

peso molecular

PEG average Mn 5,000
PLGA Mn 7,000
average Mn 12,000 (total)

prazo de degradação

1-4 weeks

temperatura de transição

Tg 24 °C
Tm 38-43 °C

PDI

<2.0

temperatura de armazenamento

2-8°C

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Descrição geral

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.

Aplicação

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
forming "stealth" pegylated microparticles

Características e benefícios

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

No data available

Ponto de fulgor (°C)

No data available

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Certificados de análise (COA)

Lot/Batch Number
MKCQ8258
MKCG9123
MKCG9125
MKCG9127
MKCG1452

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Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., &amp; Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

Artigos

Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers

One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

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