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86720

Sigma-Aldrich

Tetraethylthiuram disulfide

≥97.0% (S)

Sinônimo(s):

Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Fórmula linear:
(C2H5)2NCSS2CSN(C2H5)2
Número CAS:
97-77-8
Peso molecular:
296.54
Beilstein:
1712560
Número CE:
202-607-8
Número MDL:
MFCD00009048
Código UNSPSC:
12352100
ID de substância PubChem:
57653188
NACRES:
NA.22

Nível de qualidade

200

Ensaio

≥97.0% (S)

forma

powder

pf

69-71 °C (lit.)

cadeia de caracteres SMILES

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

chave InChI

AUZONCFQVSMFAP-UHFFFAOYSA-N

Informações sobre genes

human ... ALDH2(217) , CYP1A2(1544)

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Categorias relacionadas

Aplicação

Alcohol dehydrogenase inhibitor.

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

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PX 12 ≥98% (HPLC), powder

Sigma-Aldrich

M5324

PX 12

Mohammad Najlah et al.
Pharmaceutics, 11(11) (2019-11-20)
Disulfiram (DS), an anti-alcoholism medicine, shows strong anti-cancer activity in the laboratory, but the application in clinics for anti-cancer therapy has been limited by its prompt metabolism. Conventional liposomes have shown limited ability to protect DS. Therefore, the aim of
Peter M Meggyesy et al.
Molecules (Basel, Switzerland), 25(21) (2020-10-31)
The therapeutic utility of the copper ionophore disulfiram was investigated in a diet-induced obesity mouse model (C57BL/6J background), both through administration in feed (0.05 to 1% (w/w)) and via oral gavage (150 mg/kg) for up to eight weeks. Mice were
Beatriz Mothe et al.
The Journal of antimicrobial chemotherapy, 70(6), 1833-1842 (2015-03-01)
The safety, immunogenicity, impact on the latent reservoir and rebound of viral load after therapeutic HIV-1 vaccination with recombinant modified vaccinia Ankara-based (MVA-B) HIV-1 vaccine expressing monomeric gp120 and the fused Gag-Pol-Nef polyprotein of clade B with or without a
Boris Cvek et al.
Drug discovery today, 13(15-16), 716-722 (2008-06-27)
The major approach to the development of anticancer drugs involves searching for new compounds, efficient against malignancies, which are not, as yet, used clinically. This strategy is time-consuming and expensive. Recent studies have disclosed a surprising, but mechanistically consistent, anticancer
Colin Rae et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(6), 953-960 (2013-04-26)
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anticancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity. Our purpose was
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