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536709

Sigma-Aldrich

PAMAM dendrimer, ethylenediamine core, generation 5.0 solution

5 wt. % in methanol

Sinônimo(s):

Poly(amidoamine)

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About This Item

Fórmula linear:
[NH2(CH2)2NH2]:(G=5);dendri PAMAM(NH2)128
Número CAS:
163442-68-0
Peso molecular:
28824.81
Número MDL:
MFCD00197936
Código UNSPSC:
12162002
NACRES:
NA.23

descrição

amino surface groups

Formulário

liquid

peso molecular

generation 5.0

Características

core type ethylenediamine core (2-carbon core)

concentração

5 wt. % in methanol

Nº de grupos de superfície

128

densidade

0.797 g/mL at 25 °C

temperatura de armazenamento

2-8°C

Descrição geral

PAMAM dendrimers are water-soluble, non-immunogenic, and biocompatible symmetrical polymers. They possess a large quantity of modifiable terminal functional groups that can bind to various targeting or guest molecules. These terminal groups are used to covalently attach drugs, targeting ligands, or imaging agents for targeted delivery, controlled release, or imaging applications.

Aplicação


  • Synthesis of beta-Cyclodextrin-Decorated Dendritic Compounds Based on EDTA Core: This study presents an alternative to the ethylenediamine core in PAMAM dendrimers, using an EDTA core instead, providing insights into modifications that affect the dendrimers properties (Gonzalez Mendez et al., 2022).

  • New Advances in General Biomedical Applications of PAMAM Dendrimers: Discusses the composition variations of PAMAM dendrimer cores, including ethylenediamine, and their implications on biomedical applications (Araujo et al., 2018).

  • Poly (amidoamine) Dendrimers: Covalent and Supramolecular Synthesis: This paper reviews various synthetic strategies for PAMAM dendrimers, emphasizing the role of the ethylenediamine core in their structural formation (Lyu et al., 2019).

  • Modified Carboxyl-Terminated PAMAM Dendrimers as a Cytocompatible Nano Based Drug Delivery System: Examines the biocompatibility and drug delivery efficiency of modified PAMAM dendrimers, highlighting the cores critical role (Vu et al., 2019).

  • Use of Polyaminoamide Dendrimers Starting from Different Core-Initial Molecules for Inhibition of Silica Scale: This study explores the use of ethylenediamine-core PAMAM dendrimers in industrial applications, particularly for silica scale inhibition (Sun et al., 2021).

forma física

Contains 128 surface primary amino groups.

Informações legais

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

49.5 °F - closed cup - Methanol

Ponto de fulgor (°C)

9.7 °C - closed cup - Methanol

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Certificados de análise (COA)

Lot/Batch Number
MKCQ5446
MKCP4021
MKCN8138
MKCN2430
MKCM9640

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Zhao-Jun Liu et al.
PloS one, 11(4), e0154053-e0154053 (2016-04-23)
Stem cell therapy has emerged as a promising approach for treatment of a number of diseases, including delayed and non-healing wounds. However, targeted systemic delivery of therapeutic cells to the dysfunctional tissues remains one formidable challenge. Herein, we present a
The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine
Bharathi Devarakonda, et al.
International Journal of Pharmaceutics, 284, 133-140 (2004)
Roberta Risoluti et al.
Journal of pharmaceutical analysis, 10(4), 351-355 (2020-09-15)
In this work, functionalized carbon nanotubes (CNTs) using two polyamine polymers, polyethyleneimine (PEI) and polyamidoamine dendrimer (PAMAM), were investigated by thermal analysis in order to address preparation strategies to obtain low cytotoxic compounds with the ability to conjugate microRNAs and

Artigos

Solubility Enhancement of Poorly Water Soluble Molecules Using Dendrimers

Environmental concerns are driving the replacement of volatile organic solvents by water and aqueous mixtures. This change often creates challenges because many organic molecules show low water solubility.

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