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390704

Sigma-Aldrich

(2-Hydroxypropyl)-γ-cyclodextrin

extent of labeling: 0.6 molar substitution

Sinônimo(s):

HP-γ-CD, HPGCD, HGC

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About This Item

Número CAS:
128446-34-4
Número MDL:
MFCD16621721
Código UNSPSC:
12352201
NACRES:
NA.22

Formulário

powder

atividade óptica

[α]20/D +145°, c = 1 in H2O

peso molecular

average Mw ~1,580

Extensão da rotulagem

0.6 molar substitution

cadeia de caracteres SMILES

O1[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@H]([C@H](O[C@@H]4O[C@H]([C@H](O[C@@H]5O[C@H]([C@H](O[C@@H]6O[C@H]([C@H](O[C@@H]7O[C@H]([C@H](O[C@@H]8O[C@H]([C@H]1[C@H]([C@@H]8O)O)COCC(O)C)[C@H]([C@@H]7O)O)CO)[C@H]([C@@H]6O)O)COCC(O)C)[C@H]([C@@H]5O)O)CO)[C@H]([C@@H]4O)

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

chave InChI

ODLHGICHYURWBS-RYJYQAAZSA-N

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Descrição geral

(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.

Aplicação

(2-Hydroxypropyl)-γ-cyclodextrin may be used:
  • As a mobile phase additive in the study of the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase-high performance liquid chromatography (RP-HPLC) technique.
  • As a chiral surfactant for the analysis of econazole by micellar electrokinetic chromatography (MEKC).
  • As an analytical standard for the determination of the analyte in biological samples by HPLC.
  • As a chiral selector for the identification of propiconazole by MEKC.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCBX5998
BCBN4570V
BCBN4303V
BCBT7867
STBC5352V

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Wan Aini Wan Ibrahim et al.
Journal of chromatography. A, 1170(1-2), 107-113 (2007-10-05)
A method for the chiral separation of propiconazole using cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) with hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) as chiral selector is reported. The use of a mixture of 30 mM HP-gamma-CD, 50mM SDS, methanol-acetonitrile 10%:5% (v/v) in 25 mM phosphate
Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
Hermawan D, et al.
Journal of Pharmaceutical and Biomedical Analysis, 53(5), 1244-1249 (2010)
P K Zarzycki et al.
Analytical and bioanalytical chemistry, 391(8), 2793-2801 (2008-06-20)
The main focus of this study was to explore the capability of native alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropyl derivatives for host-guest interaction with 7,8-dimethoxyflavone, selected steroids (estetrol, estriol, estradiol, estrone, testosterone, cortisone, hydrocortisone, progesterone and 17alpha-hydroxyprogesterone) and polycyclic
Rachel J Smith et al.
The European journal of neuroscience, 30(3), 493-503 (2009-08-07)
The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist
D E Rusyniak et al.
Neuroscience, 154(4), 1619-1626 (2008-06-07)
When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown

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