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308560

Sigma-Aldrich

4-Amino-6-chloro-1,3-benzenedisulfonamide

98%

Sinônimo(s):

3-Chloroaniline-4,6-disulfonamide, 4-Amino-6-chlorobenzene-1,3-disulfonamide

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About This Item

Fórmula linear:
H2NC6H2(Cl)(SO2NH2)2
Número CAS:
121-30-2
Peso molecular:
285.73
Beilstein:
1083877
Número CE:
204-463-1
Número MDL:
MFCD00007933
Código UNSPSC:
12352100
ID de substância PubChem:
24858677
NACRES:
NA.22

Nível de qualidade

100

Ensaio

98%

forma

powder

pf

257-261 °C (lit.)

cadeia de caracteres SMILES

Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O

InChI

1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)

chave InChI

IHJCXVZDYSXXFT-UHFFFAOYSA-N

Informações sobre genes

human ... CA1(759) , CA2(760) , CA5A(763) , CA5B(11238) , CA9(768)

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Descrição geral

4-Amino-6-chloro-1,3-benzenedisulfonamide is a potent inhibitor of gastric pathogen, Helicobacter pylori (hpCA).

Aplicação

4-Amino-6-chloro-1,3-benzenedisulfonamide was used in the synthesis of deuterated thiazides by undergoing condensation with appropriately labeled aldehydes.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
STBK3661
STBJ6812
STBH0672
STBG2177V
STBD6645V

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Hydrochlorothiazide for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001494

Hydrochlorothiazide for peak identification

Hydrochlorothiazide European Pharmacopoeia (EP) Reference Standard

H1200000

Hydrochlorothiazide

Hydrochlorothiazide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1032

Hydrochlorothiazide

Hydrochlorothiazide meets USP testing specifications

Sigma-Aldrich

H2910

Hydrochlorothiazide

Mario Thevis et al.
Analytical chemistry, 74(15), 3802-3808 (2002-08-15)
The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole mass spectrometer. The mass spectra show individual and common fragmentation patterns, the generations of which
B R Thomas et al.
Journal of chromatography. B, Biomedical applications, 657(2), 383-394 (1994-07-15)
A stability-indicating, quality control analysis method was developed and validated for the diuretic drug substances hydrochlorothiazide (HCTZ) and chlorothiazide (CTZ). Micellar electrokinetic capillary chromatography employing the anionic detergent sodium dodecyl sulfate at 30 mM in 20 mM sodium borate buffer
Biopharmaceutical studies of thiazide diuretics. III. In vivo formation of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide in a patient.
T Okuda et al.
Chemical & pharmaceutical bulletin, 35(8), 3516-3518 (1987-08-01)
M Yamazaki et al.
Chemical & pharmaceutical bulletin, 38(10), 2882-2883 (1990-10-01)
2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatchard plot showed the nonlinear plot
K Deventer et al.
Journal of chromatography. A, 1216(12), 2466-2473 (2009-02-04)
In sports, thiazide diuretics are used to flush out previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. Thiazide diuretics include compounds which are very unstable and hydrolyse in
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