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222569

Sigma-Aldrich

Fomepizole

99%

Sinônimo(s):

4-Methylpyrazole

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About This Item

Fórmula empírica (Notação de Hill):
C4H6N2
Número CAS:
7554-65-6
Peso molecular:
82.10
Beilstein:
105204
Número CE:
231-445-0
Número MDL:
MFCD00005245
Código UNSPSC:
12352100
ID de substância PubChem:
24853343
NACRES:
NA.22

Ensaio

99%

índice de refração

n20/D 1.495 (lit.)

p.e.

99-100 °C/6 mmHg (lit.)

solubilidade

alcohol: soluble(lit.)
water: soluble(lit.)

densidade

0.993 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

Cc1cn[nH]c1

InChI

1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)

chave InChI

RIKMMFOAQPJVMX-UHFFFAOYSA-N

Informações sobre genes

human ... ADH1A(124) , ADH1B(125) , ADH1C(126)

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Descrição geral

4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.

Aplicação

Fomepizole (4-Methylpyrazole) can be used as:
  • A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
  • A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
  • A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Useful as an antidote in methanol and ethylene glycol poisoning.

Ações bioquímicas/fisiológicas

Alcohol dehydrogenase inhibitor
Alcohol dehydrogenase inhibitor.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319,H335

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

204.8 °F - closed cup

Ponto de fulgor (°C)

96 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análise (COA)

Lot/Batch Number
BGBC3873V
BGBC2403V
BGBC0278V
BGBB4937V
BGBB4937

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Jafar Shahraki et al.
Iranian journal of pharmaceutical research : IJPR, 12(4), 829-844 (2014-02-14)
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes
Marisa Battistella
The Annals of pharmacotherapy, 36(6), 1085-1089 (2002-05-23)
To assess the use of fomepizole in the treatment of ethylene glycol poisoning in the absence of hemodialysis. A MEDLINE search (1966-May 2001) of English-language literature pertaining to the use of fomepizole in ethylene glycol poisoning was performed. Key search
Samjhana Thapaliya et al.
Autophagy, 10(4), 677-690 (2014-02-05)
Patients with alcoholic cirrhosis and hepatitis have severe muscle loss. Since ethanol impairs skeletal muscle protein synthesis but does not increase ubiquitin proteasome-mediated proteolysis, we investigated whether alcohol-induced autophagy contributes to muscle loss. Autophagy induction was studied in: A) Human
J Samuelson et al.
Archives of medical research, 23(2), 31-33 (1992-01-01)
Ethanol is the major metabolic product of glucose fermentation by the protozoan parasite E. histolytica under the anaerobic conditions found in the lumen of the colon. With the goal of finding new targets for anti-amebic drugs, the E. histolytica NADP(+)-dependent
Amanda M Barkley-Levenson et al.
Brain sciences, 11(1) (2021-01-23)
Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene glyoxalase 1 (Glo1) has been
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