184225

Hydrogen fluoride pyridine

pyridine ~30 %, hydrogen fluoride ~70 %

• Sinônimo(s): HF-Pyridine, Olah′s reagent, PPHF, Poly(pyridine fluoride), Pyridine hydrofluoride, Pyridinium poly(hydrogen fluoride), Pyridinium polybifluoride
• Número CAS: 62778-11-4
• Beilstein: 4750151
• Número MDL: MFCD00012436
• Código UNSPSC: 12352301
• ID de substância PubChem: 24851101
• NACRES: NA.22

Propriedades

• Formulário: liquid
• Nível de qualidade: 200
• composição: hydrogen fluoride, ~70% ; pyridine, ~30%
• densidade: 1.1 g/mL at 20 °C (lit.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: F[H].c1ccncc1
• InChI: 1S/C5H5N.FH/c1-2-4-6-5-3-1;/h1-5H;1H
• chave InChI: GRJJQCWNZGRKAU-UHFFFAOYSA-N

Descrição

Descrição geral

May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.

Aplicação

Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.
Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor^® (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.

Reactant for preparation of:

• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorination

Reagent for:

• Halofluorination reactions

Informações legais

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06,GHS05
• Palavra indicadora: Danger
• Frases de perigo: H300 + H310 + H330,H314
• Declarações de precaução: P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter