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183733

Sigma-Aldrich

4′-(Imidazol-1-yl)acetophenone

96%

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About This Item

Fórmula empírica (Notação de Hill):
C11H10N2O
Número CAS:
10041-06-2
Peso molecular:
186.21
Número CE:
233-123-5
Número MDL:
MFCD00005282
Código UNSPSC:
12352005
ID de substância PubChem:
24851074

Nível de qualidade

100

Ensaio

96%

forma

solid

pf

108-110 °C (lit.)

cadeia de caracteres SMILES

CC(=O)c1ccc(cc1)-n2ccnc2

InChI

1S/C11H10N2O/c1-9(14)10-2-4-11(5-3-10)13-7-6-12-8-13/h2-8H,1H3

chave InChI

GAIQQJIMVVUTQN-UHFFFAOYSA-N

Categorias relacionadas

Descrição geral

4′-(Imidazol-1-yl)acetophenone is a selective thromboxane synthesis inhibitor.

Aplicação

4′-(Imidazol-1-yl)acetophenone was used in the synthesis of (R)-(+)-4′-(imidozol-1-yl)-phenyl ethanol using spiroborate catalyst.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315 - H319 - H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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H D Uderman et al.
Prostaglandins, 24(2), 237-244 (1982-08-01)
The compound 4'-(imidazol-1-yl) acetophenone was demonstrated to be a selective thromboxane (Tx) synthetase inhibitor in spontaneously hypertensive rats (SHR). Serum TxB2 concentrations (from clotted blood) were suppressed by 89.1% (p less than 0.001) and 41.2% (p less than 0.01) at
W D Watkins et al.
Prostaglandins, 23(3), 273-285 (1982-03-01)
We assessed the effect of a specific thromboxane synthetase inhibitor (an imidazole derivative) on pulmonary hemodynamics and the concentrations of TxB2 (TxA2), 6-keto-PGF1 alpha (PGI2), and PGF2 in pulmonary lymph and transpulmonary blood samples following intravenous administration of E. coli
P A Craven et al.
The Journal of laboratory and clinical medicine, 116(4), 469-478 (1990-10-01)
Thromboxane contributes to the regulation of glomerular hemodynamics in experimental models of diabetes and has been implicated as mediator in some models of glomerular injury. In the present study we examined urinary albumin, protein, and thromboxane B2 (TXB2) excretion during
Viatcheslav Stepanenko et al.
Tetrahedron, asymmetry, 18(23), 2738-2745 (2007-11-26)
The effectiveness of several spiroborate ester catalysts was investigated in the asymmetric borane reduction of 2-, 3-, 4-acetylpyridines under different reaction conditions. Highly enantiomerically enriched 1-(2-, 3- and 4-pyridyl)ethanols and 1-(heterocyclic)ethanols were obtained using 1 to 10% catalytic loads of
J Triscari et al.
International journal of obesity, 11 Suppl 3, 43-51 (1987-01-01)
A selective inhibitor of thromboxane synthase, Ro 22-3581 has been shown to be a useful tool for investigating the relationship between hyperinsulinemia and obesity. These studies have established that the pharmacologic normalization of the hyperinsulinemia associated with elevated weights in
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