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Merck

GRIN2B

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Sinônimos:
GluN2B, MRD6, NMDAR2B, NR2B, hNR3
Espécies:
ID UniProtKB:
ID do gene:
  • Human(2904) Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
  • Mouse(14812) glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Rat(24410) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • chicken(417965) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • dog(494009) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic cat(101094356) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • Horse(100063746) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • cow(537804) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic guinea pig(100731840) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • naked mole-rat(101723091) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • sheep(101118179) glutamate receptor, ionotropic, N-methyl D-aspartate 2B

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Small Molecule - Agonist

Número do produto
Descrição
Espécies
Reversin 205, ≥98% (HPLC), film,
Espécies
mouse, rat, human
D-Cycloserine, synthetic,
Espécies
human
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Espécies
human
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Espécies
human, rat
(S)-AMPA, ≥97%,
Espécies
mouse, human, rat

Small Molecule - Allosteric Modulator

Número do produto
Descrição
Espécies
Acamprosate calcium, ≥98% (HPLC), powder,
Espécies
human
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Espécies
human

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
DL-2-Aminoadipic acid, ≥99%,
Espécies
rat
2-Phenylquinoline, 99%,
Espécies
rat
Ro 25-6981 hydrochloride hydrate, ≥98% (HPLC), powder,
Espécies
human
Ro 8-4304, solid,
Espécies
human
Spermine, ≥97%,
Espécies
rat, human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
PhosphoDetect Anti-NMDA NR2B (pTyr¹⁴⁷²) Rabbit pAb, liquid, Calbiochem®,
Reatividade de espécies
rat
Aplicação
Anti-GRIN2B antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
horse, human, mouse, rabbit, rat
Aplicação
immunohistochemistry
western blot
Anti-NMDAR2B Antibody, clone 5C18 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
bovine, canine, feline, monkey, mouse, rat
Aplicação
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-GRIN2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
Anti-NMDAR2B antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
western blot

Small Molecule - Blocker

Número do produto
Descrição
Espécies
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Espécies
human
Agmatine sulfate salt, ≥97%, powder,
Espécies
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Espécies
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Espécies
human

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
Pentamidine isethionate salt, powder,
Espécies
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Espécies
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espécies
rat, human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human GRIN2B,
Espécies
human
MISSION® esiRNA, targeting mouse Grin2b,
Espécies
mouse