R0158

RepSox

≥98% (HPLC), solid, TGF-β RI kinase inhibitor

• Synonyme(s) : E-616452; 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
• Formule empirique (notation de Hill): C₁₇H₁₃N₅
• Numéro CAS: 446859-33-2
• Poids moléculaire : 287.32
• Numéro MDL: MFCD09037561
• Code UNSPSC : 51111800
• ID de substance PubChem : 329823975
• Nomenclature NACRES : NA.77

Propriétés

• product name: RepSox, ≥98% (HPLC)
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Solubilité: DMSO: >20 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3
• InChI: 1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
• Clé InChI: LBPKYPYHDKKRFS-UHFFFAOYSA-N

Description

Application

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Actions biochimiques/physiologiques

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

RepSox inhibits osteoclast differentiation, resorption in bone tissues and ovariectomy (OVX)‐induced osteoporosis (OP) through repression of the SMAD family member 3 (Smad3) and c-Jun N-terminal kinase (JNK) pathway/ activator protein 1 (AP-1) pathways.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable