SML0305

3-Deazaneplanocin A hydrochloride

≥97% (HPLC)

• Synonyme(s) : (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride, DZNep hydrochloride
• Formule empirique (notation de Hill): C₁₂H₁₄N₄O₃ · HCl
• Numéro CAS: 120964-45-6
• Poids moléculaire : 298.73
• Numéro MDL: MFCD18782644
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825310
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥97% (HPLC)
• Forme: powder
• Activité optique: [α]/D -88 to -108°, c = 0.1 in water
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: ≥5 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: Cl.Nc1nccc2n(cnc12)[C@@H]3C=C(CO)[C@@H](O)[C@H]3O
• InChI: 1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/m1./s1
• Clé InChI: UNSKMHKAFPRFTI-FDKLLANESA-N

Description

Description générale

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.

Application

3-Deazaneplanocin A hydrochloride has been used to examine the potential involvement of autophagy and apoptosis in colorectal cancer (CRC) cells.

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.

Actions biochimiques/physiologiques

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable