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S5567

SP600125

Name: SP600125
Brand: SIGMA

≥98% (HPLC), powder or solid, JNK inhibitor

Synonyme(s) :

1,9-Pyrazoloanthrone, Anthrapyrazolone

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About This Item

Formule empirique (notation de Hill):

C₁₄H₈N₂O

Numéro CAS:

129-56-6

Poids moléculaire :

220.23

Numéro CE :

204-955-6

Numéro MDL:

MFCD00022289

Code UNSPSC :

12352200

ID de substance PubChem :

24278395

Nomenclature NACRES :

NA.77

product name

SP600125, ≥98% (HPLC)

Pureté

≥98% (HPLC)

Couleur

yellow

Solubilité

DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow
H₂O: insoluble

Température de stockage

2-8°C

Chaîne SMILES

O=C1c2ccccc2-c3n[nH]c4cccc1c34

InChI

1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)

Clé InChI

ACPOUJIDANTYHO-UHFFFAOYSA-N

Informations sur le gène

human ... JUN(3725) , MAPK10(5602) , MAPK9(5601)

Application

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.¹¹ It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.¹²

Actions biochimiques/physiologiques

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.^8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.¹⁰

A novel and selective inhibitor of c-Jun N-terminal kinase (JNK)

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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β-Conglycinin-Induced Intestinal Porcine Epithelial Cell Damage via the Nuclear Factor κB/Mitogen-Activated Protein Kinase Signaling Pathway.

Chenglu Peng et al.

Journal of agricultural and food chemistry, 67(32), 9009-9021 (2019-07-19)

Soybean allergy is a serious health risk to humans and animals; β-conglycinin is the primary antigenic protein in soybean. Intestinal porcine epithelial (IPEC-J2) cells were used as an in vitro physiological model of the intestinal epithelium to study the effects

Apolipoprotein E Affects In Vitro Axonal Growth and Regeneration via the MAPK Signaling Pathway.

Cheng Yin et al.

Cell transplantation, 28(6), 691-703 (2018-10-24)

Following central nervous system injury in mammals, failed axonal regeneration is closely related to dysneuria. Previous studies have shown that the obvious effects of apolipoprotein E (ApoE) on traumatic brain injury (TBI) were associated with an axonal mechanism. However, little

Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis.

Donia Mili et al.

Molecular cytogenetics, 9, 86-86 (2016-12-08)

The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking mitosis progression and inducing cell death. Despite, all this study, the mechanism by which SP600125 inhibits mitosis-related effects in human cervical cells (HeLa cells) remains

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.

Adrian Vallejo et al.

Nature communications, 8, 14294-14294 (2017-02-22)

KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report

PDZ Scaffold Protein CAL Couples with Metabotropic Glutamate Receptor 5 to Protect Against Cell Apoptosis and Is a Potential Target in the Treatment of Parkinson's Disease.

Wen Yuan Luo et al.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 16(3), 761-783 (2019-05-11)

Targeting mGluR5 has been an attractive strategy to modulate glutamate excitotoxicity for neuroprotection. Although human clinical trials using mGluR5 negative allosteric modulators (NAMs) have included some disappointments, recent investigations have added several more attractive small molecules to this field, providing

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Naive Pluripotent Stem Cell Culture in an Inhibitor Based 2i/LIF Containing Serum-Free and Feeder-Free Stem Cell Media

Naive pluripotent stem cells are located within the epiblast of mature blastocysts. These primitive “ground-state” cells may be cultured in vitro using specialized media and small molecule inhibitors.

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