U6508

UCN-01

≥97% (HPLC), powder

• Synonym(e): KW-2401
• Empirische Formel (Hill-System): C₂₈H₂₆N₄O₄
• CAS-Nummer: 112953-11-4
• Molekulargewicht: 482.53
• MDL-Nummer: MFCD26960886
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724639
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Optische Aktivität: [α]20/D 130 to 160°, c = 0.2 in DMSO
• Lagerbedingungen: protect from light
• Farbe: light yellow
• Löslichkeit: DMSO: >5 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: [H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8
• InChI: 1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
• InChIKey: PBCZSGKMGDDXIJ-HQCWYSJUSA-N
• Angaben zum Gen: human ... CDK2(1017) , CDK4(1019) , CDK6(1021) , CHEK1(1111) , PDPK1(5170) , PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584) , PRKCQ(5588) , PRKCZ(5590) , PRKD1(5587) , PRKD3(23683)

Beschreibung

Anwendung

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

Biochem./physiol. Wirkung

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

Leistungsmerkmale und Vorteile

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable