SML1109

KU-55933

≥98% (HPLC)

• Synonym(e): 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-Pyran-4-one, 2-(Morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one
• Empirische Formel (Hill-System): C₂₁H₁₇NO₃S₂
• CAS-Nummer: 587871-26-9
• Molekulargewicht: 395.49
• MDL-Nummer: MFCD08276985
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825484
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5
• InChI: 1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
• InChIKey: XRKYMMUGXMWDAO-UHFFFAOYSA-N

Beschreibung

Anwendung

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Biochem./physiol. Wirkung

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC₅₀ = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable