P5514

Mepyramin -maleat (Salz)

• Synonym(e): N-(4-Methoxyphenyl)-methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethandiamin, Pyrilamin -maleat (Salz)
• Empirische Formel (Hill-System): C₁₇H₂₃N₃O · C₄H₄O₄
• CAS-Nummer: 59-33-6
• Molekulargewicht: 401.46
• EG-Nummer: 200-422-7
• MDL-Nummer: MFCD00069333
• UNSPSC-Code: 12352116
• PubChem Substanz-ID: 24277797
• NACRES: NA.77

Eigenschaften

• Form: powder
• Ersteller: Watson
• SMILES String: OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
• InChI: 1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: JXYWFNAQESKDNC-BTJKTKAUSA-N
• Angaben zum Gen: human ... HRH1(3269)

Beschreibung

Anwendung

Pyrilamine maleate salt has been used:

• to treat Cassiopea sp. as H₁ receptor antagonist
• to intraperitoneally inject mice to prevent the release of endogenous histamine
• in membrane binding assay to determine the K_i values and in the comparative inhibitory concentration (IC₅₀) studies by whole-cell patch clamp technique

Biochem./physiol. Wirkung

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves