P6126

(R)-(−)-Phenylephrin -hydrochlorid

≥99% (titration), powder, α₁-adrenoceptor agonist

• Synonym(e): (R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol -hydrochlorid, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)-benzylalkohol -hydrochlorid
• Lineare Formel: HOC₆H₄CH(CH₂NHCH₃)OH·HCl
• CAS-Nummer: 61-76-7
• Molekulargewicht: 203.67
• Beilstein: 4158948
• EG-Nummer: 200-517-3
• MDL-Nummer: MFCD00012605
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 57654535
• NACRES: NA.77

Eigenschaften

• product name: (R)-(−)-Phenylephrin -hydrochlorid, powder
• Form: powder
• Qualitätsniveau: 200
• mp (Schmelzpunkt): 143-145 °C (lit.)
• Ersteller: Johnson & Johnson
• SMILES String: OC1=CC([C@H](CNC)O)=CC=C1.Cl
• InChI: 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
• InChIKey: OCYSGIYOVXAGKQ-FVGYRXGTSA-N
• Angaben zum Gen: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Beschreibung

Allgemeine Beschreibung

(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.

Anwendung

(R)-(-)-Phenylephrine hydrochloride has been used:

• in the preparation and culturing of cardiocytes and fibroblasts
• to stimulate myocardial strips to measure slice contraction
• in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo
• to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes
• to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality

Biochem./physiol. Wirkung

α₁-Adrenoceptor Agonist.

Leistungsmerkmale und Vorteile

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H317
• P-Sätze: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Gefahreneinstufungen: Acute Tox. 4 Oral - Skin Sens. 1B
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves