D1069

Desloratadin

powder, ≥98% (HPLC)

• Synonym(e): 8-Chlor-6,11-dihydro-11-(4-piperidinyliden)-5H-benzo[5,6]cyclohepta[1,2,b]pyridin, Clarinex^®, NSC 675447
• Empirische Formel (Hill-System): C₁₉H₁₉ClN₂
• CAS-Nummer: 100643-71-8
• Molekulargewicht: 310.82
• MDL-Nummer: MFCD00871949
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798668
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
• InChI: 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• InChIKey: JAUOIFJMECXRGI-UHFFFAOYSA-N
• Angaben zum Gen: human ... HRH1(3269)

Beschreibung

Anwendung

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.

Biochem./physiol. Wirkung

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Rechtliche Hinweise

Clarinex is a registered trademark of Schering Corp.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): 390.2 °F - Pensky-Martens closed cup
• Flammpunkt (°C): 199 °C - Pensky-Martens closed cup