C0250000

Calciumfolinat

European Pharmacopoeia (EP) Reference Standard

• Synonym(e): Folinsäure Calciumsalz Hydrat, 5-Formyl-5,6,7,8-tetrahydrofolsäure Calciumsalz, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutaminsäure Calciumsalz, 5-HCO-H₄PteGlu, Calciumfolinat, Citrovorum-Faktor Calciumsalz, Leucovorin Calciumsalz
• Empirische Formel (Hill-System): C₂₀H₂₁CaN₇O₇ · xH₂O
• CAS-Nummer: 1492-18-8
• Molekulargewicht: 511.50 (anhydrous basis)
• Beilstein: 5723924
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Biologische Quelle: synthetic
• Qualität: pharmaceutical primary standard
• Agentur: EP
• API-Familie: folic acid
• Form: solid
• Hersteller/Markenname: EDQM
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
• InChI: 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
• InChIKey: KVUAALJSMIVURS-ZEDZUCNESA-L

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. Calcium folinate (CF) is a folic acid derivative. It is a naturally occurring compound that has a vital role in various metabolic pathways. Calcium folinate (CF) drug is also used in the treatment of anemia, during pregnancy.

Anwendung

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Verpackung

Dieses Produkt wird, wie von der entsprechenden Pharmakopöe geliefert, angeboten. Die aktuellen Mengeneinheiten finden Sie im Referenzsubstanzen-Katalog der EDQM.

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable