902551

BocNH-PEG4-acid

• Synonym(e): 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH₂COOH
• Empirische Formel (Hill-System): C₁₅H₂₉NO₈
• CAS-Nummer: 876345-13-0
• Molekulargewicht: 351.39
• UNSPSC-Code: 12352106
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Eignung der Reaktion: reaction type: Pegylations; reagent type: cross-linking reagent
• Brechungsindex: n/D 1.4641
• Dichte: 1.1395 g/mL
• Funktionelle Gruppe: Boc; amine; carboxylic acid
• Lagertemp.: −20°C
• SMILES String: OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Sonstige Hinweise

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable