764221

Propargyl-N-hydroxysuccinimidyl ester

• Synonym(e): 2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate, 3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester, Alkyne-NHS ester, Propargyl-succinimidyl-ester
• Empirische Formel (Hill-System): C₁₀H₁₁NO₅
• CAS-Nummer: 1174157-65-3
• Molekulargewicht: 225.20
• MDL-Nummer: MFCD13184973
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 329767108

Eigenschaften

• Form: solid
• Qualitätsniveau: 100
• Eignung der Reaktion: reaction type: click chemistry; reagent type: cross-linking reagent
• mp (Schmelzpunkt): 36-41 °C
• Funktionelle Gruppe: NHS ester; alkyne
• Lagertemp.: −20°C
• SMILES String: C#CCOCCC(ON1C(CCC1=O)=O)=O
• InChI: 1S/C10H11NO5/c1-2-6-15-7-5-10(14)16-11-8(12)3-4-9(11)13/h1H,3-7H2
• InChIKey: WKIKHHMUNOVQLD-UHFFFAOYSA-N

Beschreibung

Anwendung

Propargyl-N-hydroxysuccinimidyl ester may be used as a tool for identifying nucleophilic ligandable hotspots by chemoproteomic approaches.

Propargyl-NHS ester is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc, with a terminal alkyne. The alkyne can be reacted with an azide containing compound or biomolecule via copper catalyzed azide-alkyne click chemistry to yield a stable triazole linkage.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable