901566

Propargyl-PEG₂-acid

• Empirische Formel (Hill-System): C₈H₁₂O₄
• CAS-Nummer: 1859379-85-3
• Molekulargewicht: 172.18
• UNSPSC-Code: 12352106
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Eignung der Reaktion: reaction type: click chemistry; reagent type: linker
• Funktionelle Gruppe: alkyne; carboxylic acid
• Lagertemp.: −20°C
• SMILES String: C#CCOCCOCCC(O)=O

Beschreibung

Anwendung

Propargyl-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains two PEG units to help improve solubility.

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3