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1003009

USP

Acetaminophen

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Acetaminophen, 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol

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About This Item

Linear Formula:
CH3CONHC6H4OH
CAS Number:
103-90-2
Molecular Weight:
151.16
Beilstein/REAXYS Number:
2208089
MDL number:
MFCD00002328
UNSPSC Code:
41116107
PubChem Substance ID:
329748124
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

acetaminophen, paracetamol

manufacturer/tradename

USP

mp

168-172 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

Gene Information

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetaminophen USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Acetaminophen Tablets
  • Acetaminophen Capsules
  • Acetaminophen Suppositories
  • Acetaminophen Oral Suspension
  • Acetaminophen Oral Solution
  • Acetaminophen and Caffeine Tablets
  • Acetaminophen Extended-Release Tablets

Analgesic.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Related product

Product No.
Description
Pricing

PHR1148

4-Aminophenol (Acetaminophen Related Compound K) (Paracetamol Impurity K), Pharmaceutical Secondary Standard; Certified Reference Material

PHR1149

Acetaminophen Related Compound J, Pharmaceutical Secondary Standard; Certified Reference Material

1021204

4-Aminophenol, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-Aminophenol, Pharmaceutical Secondary Standard; Certified Reference Material

1003010

Acetaminophen Related Compound A, United States Pharmacopeia (USP) Reference Standard

P0300000

Paracetamol, European Pharmacopoeia (EP) Reference Standard

PHR1531

Acetaminophen Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1530

Acetaminophen Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1612

Acetaminophen Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1003042

Acetaminophen Related Compound D, United States Pharmacopeia (USP) Reference Standard

1003100

Acetaminophen Related Compound J, United States Pharmacopeia (USP) Reference Standard

Y0001781

Paracetamol for equipment qualification, European Pharmacopoeia (EP) Reference Standard

BP371

Paracetamol, British Pharmacopoeia (BP) Reference Standard

Y0001955

Paracetamol impurity K, European Pharmacopoeia (EP) Reference Standard

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

364.3 °F - Pensky-Martens closed cup

flash_point_c

184.6 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Acetaminophen
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(6), 38-38 (2020)
Acetaminophen tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(3), 45-45 (2021)
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure
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HPLC Analysis of Pain Relievers on Ascentis® Express C18

Separation of Acetaminophen, meets USP testing specifications, 98.0-102.0%, powder; Caffeine, meets USP testing specifications, anhydrous; Benzoic acid, meets USP testing specifications; Aspirin, meets USP testing specifications

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