SRP6374
Galectin-9 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
Ecalectin, Gal-9, LGALS9, Tumor antigen HOM-HD-21
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
18.5 kDa (168 aa, 1-148 aa + His Tag.)
packaging
pkg of 50 μg
concentration
0.5 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... LGALS9(3965)
General description
Galectin-9 (Gal-9) is a member of animal lectins that have an affinity to β-galactosides and Forssman pentasaccharide. It is strongly overexpressed in Hodgkin′s disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. Recombinant Galectin-9 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Physical form
0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM NaCl and 20% glycerol.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Judith Leitner et al.
PLoS pathogens, 9(3), e1003253-e1003253 (2013-04-05)
T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and
Anthony L Steichen et al.
PloS one, 10(4), e0123573-e0123573 (2015-04-22)
Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis. Here we show that Galectin-9, a host endogenous β-galactoside
R Mukherjee et al.
Food & function, 10(1), 33-37 (2019-01-12)
Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ
Elizabeth Ann L Enninga et al.
The Journal of pathology, 245(4), 468-477 (2018-05-08)
In patients with metastatic melanoma, high blood levels of galectin-9 are correlated with worse overall survival and a bias towards a Th2 inflammatory state supportive of tumor growth. Although galectin-9 signaling through TIM3 on T cells has been described, less
Susanna Leskela et al.
PloS one, 10(4), e0123938-e0123938 (2015-04-17)
Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with AITD. Peripheral blood samples from 25 patients with
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