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Key Documents

SRP0444

Sigma-Aldrich

A20 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥20% (SDS-PAGE)

Synonym(s):

OTU domain-containing protein 7C, OTUD7C, TNFAIP3, tumor necrosis factor-? induced protein 3

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥20% (SDS-PAGE)

form

aqueous solution

mol wt

90.5 kDa

packaging

pkg of 50 μg

NCBI accession no.

NM_006290

UniProt accession no.

P21580

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TNFAIP3(7128)

General description

Human A20, also known as tumor necrosis factor-α induced protein 3 (TNFAIP3) or OTU domain-containing protein 7C (OTUD7C), (GenBank Accession No. NM_006290) amino acids 2-791(end) with an N-terminal FLAG-tag, MW=90.5 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jing Liu et al.
Journal of biomedical science, 20, 74-74 (2013-10-09)
Intestinal polyps may further develop into colon cancer; the pathogenesis is not clear. The p53 gene is an important anti-cancer gene in the body, which is suppressed in cancer. The ubiquitin E3 ligase A20 (A20) plays a role in regulating
Chong-Shan Shi et al.
Autophagy, 6(7), 986-987 (2010-08-28)
Toll-like receptor 4 (TLR4) signaling triggers autophagy, which has been linked to both adaptive and innate immunity. Engagement of TLR4 recruits to the receptor complex Beclin 1, a key component of a class III phosphatidylinositol 3-kinase complex (PI3KC3) that initiates
Sarah G Hymowitz et al.
Nature reviews. Cancer, 10(5), 332-341 (2010-04-13)
Clinicians have suspected for hundreds of years that chronic activation of the immune system contributes to the development of cancer. However, the molecular mechanisms that mediate this precarious interplay are only now being elucidated. Recent reports have identified A20 as
Rita M Tavares et al.
Immunity, 33(2), 181-191 (2010-08-14)
A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against tumor necrosis factor (TNF)-induced programmed cell death. Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus erythematosus (SLE), we have generated

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