SML3600

AZ10606120 dihydrochloride

≥98% (HPLC)

• Synonym(s): 2-(1-Adamantyl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]acetamide dihydrochloride, AZ 10606120 dihydrochloride, AZ-10606120 dihydrochloride, Compound-17 dihydrochloride, N-[2-({2-[(2-Hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidee dihydrochloride
• Empirical Formula (Hill Notation): C₂₅H₃₄N₄O₂·2HCl
• CAS Number: 607378-18-7
• Molecular Weight: 495.48
• UNSPSC Code: 51111800
• UNSPSC Code: 12352200
• NACRES: NA.04

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated; protect from light; under inert gas
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (Warmed)
• storage temp.: room temp
• SMILES string: O=C(NC1=CC=CC2=C1C=CC(NCCNCCO)=N2)CC3(C[C@H]4C5)C[C@@H](C4)C[C@@H]5C3.[2HCl]

Description

Biochem/physiol Actions

AZ-10606120 is a potent purinoceptor P2X7 negative allosteric modulator that antagonizes ATP-dependent P2X7 activation (IC50 against ATP-induced ethidium bromide uptake = 2.3 nM and 24 nM, respectively, using human or rat P2X7 HEK293 transfectants; [ATP] = EC50) in a non-competitive and slowly reversible manner via affinity interaction at an allosteric pocket (human/rat P2X7 KD = 1.4 nM/19 nM) distinct from the KN-62- or ATP-binding site. A useful tool for probing P2X7-mediated physiological and pathological processes both in cultures (0.1-10 µM) and in vivo (e.g. 5 mg/kg i.p., 300 nM i.m., or 3 µg i.c.v.; in mice).

Potent purinoceptor P2X7 negative allosteric modulator that antagonizes ATP-dependent P2X7 activation in a non-competitive and slowly reversible manner.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable