SML3412

Talinolol

≥95% (HPLC)

• Synonym(s): (±)-Talinolol, 02-115, 1-(4-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea, 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane, Cordanum, N-Cyclohexyl-N′-[4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]urea, rac-Talinolol
• Empirical Formula (Hill Notation): C₂₀H₃₃N₃O₃
• CAS Number: 57460-41-0
• Molecular Weight: 363.49
• MDL number: MFCD00864592
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• InChI: 1S/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25)
• InChI key: MXFWWQICDIZSOA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Talinolol is an orally active beta blocker (β blocker) with in vivo antihypertensive efficacy. In addition to its beta-adrenergic receptor (βAR, bAR) antagonist potency (βAR1/2 Ki = 0.24/0.9 μM), talinolol is also reported to exhibit inhibitory side-activity against soluble epoxide hydrolase (sEH IC50 = 2.8 μM).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable