SML3406

Nutlin-3b

≥98% (HPLC)

• Synonym(s): 4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone, Nutlin 3b
• Empirical Formula (Hill Notation): C₃₀H₃₀Cl₂N₄O₄
• CAS Number: 675576-97-3
• Molecular Weight: 581.49
• MDL number: MFCD11978162
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: ClC(C=C1)=CC=C1[C@@H]2[C@H](C3=CC=C(Cl)C=C3)N(C(N4CCNC(C4)=O)=O)C(C5=C(OC(C)C)C=C(OC)C=C5)=N2
• InChI: 1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
• InChI key: BDUHCSBCVGXTJM-IZLXSDGUSA-N

Description

Biochem/physiol Actions

Nutlin-3b, a (+)-enantiomer of Nutlin-3, is a weakly potent antagonist of p53/MDM2 (IC50 = 13.6 μM) that can serve as negative control for Nutlin-3a (IC50 = 90 nM) and other Mdm2 inhibitors.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable