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Key Documents

SML3394

Sigma-Aldrich

GZ-11608

≥98% (HPLC)

Synonym(s):

4-​Methoxy-​N-​[(1S)​-​1-​methyl-​2-​phenylethyl]​-benzenepropanamine, S-3-(4-Methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine

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About This Item

Empirical Formula (Hill Notation):
C19H25NO
CAS Number:
2141974-01-6
Molecular Weight:
283.41
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

assay

≥98% (HPLC)

form

oil

color

colorless to brown

storage temp.

2-8°C

SMILES string

N([C@H](Cc2ccccc2)C)CCCc1ccc(cc1)OC

InChI key

LKTLDVZCNLGHOG-INIZCTEOSA-N

Biochem/physiol Actions

GZ-11608 is a potent and selective inhibitor of vesicular monoamine transporter-2 (VMAT2) that diminished hERG interaction. GZ-11608 reduces behavioral effects of methamphetamine such as locomotor activity, self-administration, and methamphetamine seeking behavior. It does not exhibit abuse liability. GZ-11608 inhibits methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons.
Potent and selective inhibitor of vesicular monoamine transporter-2 (VMAT2)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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