SML3373
BZ194
≥98% (HPLC)
Synonym(s):
3-Carboxy-1-[2-(octylamino)-2-oxoethyl]pyridinium bromide, 3-Carboxy-1-octylcarbamoylmethyl-pyridinium bromide, BZ 194, BZ-194
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About This Item
Empirical Formula (Hill Notation):
C16H25BrN2O3
CAS Number:
Molecular Weight:
373.29
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C[N+]1=CC(C(O)=O)=CC=C1)NCCCCCCCC.[Br-]
Biochem/physiol Actions
BZ194 is a selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to type 1 ryanodine receptor (RYR-1; IC50 ~10 uM against 1 uM NAADP). BZ194 inhibits Ca(2+) mobilization induced by NAADP (IC50 ~3 uM co-injected with 100 nM NAADP into Jurkat T cells), but not Ins(1,4,5)P3 or cyclic ADP-ribose (cADPR), and exhibits no inhibitory potency against capacitative Ca(2+) entry.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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