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Key Documents

SML1186

Sigma-Aldrich

GGTI-286 dihydrochloride

≥90% (HPLC)

Synonym(s):

(R)-N-[[5-[(2-Amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-L-lLeucine methyl ester dihydrochloride, GGTI 286 dihydrochloride, N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-L-leucine methyl ester dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H31N3O3S · 2HCl
CAS Number:
171744-11-9
Molecular Weight:
502.50
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥90% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) that selectively disrupts oncogenic K-Ras4B. New study shows that GGTI-286 reduces nuclear localization of β-catenin.

Other Notes

Air sensitive; dessicant.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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