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SML0508

Sigma-Aldrich

Pentostatin

≥95% (HPLC)

Synonym(s):
2′-dCF, (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, DCF, Deoxycoformycin
Empirical Formula (Hill Notation):
C11H16N4O4
CAS Number:
Molecular Weight:
268.27
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D +70 to +80°, c = 1 in H2O

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23

InChI

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChI key

FPVKHBSQESCIEP-JQCXWYLXSA-N

Gene Information

human ... ADA(100)

Application

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.
Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air sensitve; hygroscopic.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Hagay Kohay et al.
Journal of colloid and interface science, 552, 517-527 (2019-06-04)
Polycation conformation upon adsorption to a negatively charged surface can be modulated by its charge density. At high charge density monomers directly interact with the surface in a 'trains' conformation and as charge density decreases a high degree of monomers
Lucie Svobodníková et al.
Ecotoxicology and environmental safety, 182, 109369-109369 (2019-06-27)
Growth and developmental changes in plants induced by pharmaceuticals reflect changes in processes at the cellular and subcellular levels. Due to their growth and cellular characteristics, plant cell suspension cultures can be a suitable model for assessing toxicity. In this
Hairy-cell leukemia: induction of complete remission with pentostatin (2'-deoxycoformycin).
Spiers AS, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2(12), 1336-1342 (1984)
Pentostatin, cyclophosphamide and rituximab is a safe and effective treatment in patients with Waldenstrom?s macroglobulinemia
Herth I, et al.
Leukemia Lymphoma, 56(1), 97-102 (2015)
Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation
Liu S, et al.
Testing, 8(39), 65123-65123 (2017)

Articles

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