SAB5703048

Anti-CD40 Antibody, clone 5V8X7, Rabbit Monoclonal

• Synonym(s): CD40,Bp50,CDW40,TNFRSF5,p50
• UNSPSC Code: 12352203
• NACRES: NA.46

Properties

• biological source: rabbit
• Quality Level: 100
• material: colorless
• clone: 5V8X7, monoclonal
• form: liquid
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): flow cytometry: 1:50 - 1:200
• color: colorless
• isotype: IgG
• UniProt accession no.: P25942
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CD40(958)

Description

General description

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Immunogen

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

Recombinant protein of human CD40

Application

FC

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2