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Key Documents

SAB4501467

Sigma-Aldrich

Anti-APLP2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

APLP2, APP2, APPH, Amyloid protein homolog, Amyloid-like protein 2 precursor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 86 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

Q06481

UniProt accession no.

Q06481

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APLP2(334)

Related Categories

General description

Anti-APLP2 Antibody detects endogenous levels of total APLP2 protein.
APLP2 (amyloid precursor-like protein 2) belongs to the amyloid precursor protein family. It is mapped to human chromosome 11q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human APLP2.

Immunogen Range: 241-290

Biochem/physiol Actions

Amyloid precursor-like protein 2 (APLP2) aids in the proliferation of pancreatic cancer growth and metastasis. It controls the expression of cell surface proteins. APLP2 plays an important role in chromosome replication and segregation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation.
Tuli A, et al.
The Journal of Biological Chemistry, 284(49), 34296-34307 (2009)
Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis.
Collin RW, et al.
European Journal of Biochemistry, 271(10), 1906-1912 (2004)
Poomy Pandey et al.
Oncotarget, 6(4), 2064-2075 (2015-01-13)
Amyloid precursor-like protein 2 (APLP2) is aberrantly expressed in pancreatic cancer. Here we showed that APLP2 is increased in pancreatic cancer metastases, particularly in metastatic lesions found in the diaphragm and intestine. Examination of matched human primary tumor-liver metastasis pairs

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