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Key Documents

SAB4500961

Sigma-Aldrich

Anti-FLT3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CD135 antigen, STK-1, Stem cell tyrosine kinase 1, Tyrosine-protein kinase receptor FLT3

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About This Item

MDL number:
MFCD01864666
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 112 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI accession no.

P36888

UniProt accession no.

P36888

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FLT3(2322)

General description

Anti-FLT3 antibody detects endogenous levels of total FLT3 protein.
FLT3 (Fms-like tyrosine kinase) is a member of tyrosine kinase (RTK) family. It has an extracellular domain consisting of five immunoglobulin-like domains and an intracellular kinase domain interrupted by a kinase insert. It is located on human chromosome 13q12.

Immunogen

The antiserum was produced against synthesized peptide derived from human FLT3.

Immunogen Range: 565-614

Biochem/physiol Actions

Mutation in FLT3 (Fms-like tyrosine kinase) results in acute myeloid leukemia and it also induces warburg effect and offers therapeutic sensitivity to glycolytic inhibition.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition
Ju HQ, et al.
Leukemia, 31(10), 2143-2143 (2017)
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
Kazi JU, et al.
Cellular and Molecular Life Sciences, 74(14), 2679-2688 (2017)
Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
Tracy S, et al.
Cancer Research, 64(20), 7241-7244 (2004)

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