SAB4300041

Anti-phospho-ATF4 (pSer²⁴⁵) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CREB-2 antibody produced in rabbit, Anti-CREB2 antibody produced in rabbit, Anti-TAXREB67 antibody produced in rabbit, Anti-TXREB antibody produced in rabbit, Anti-activating transcription factor 4 (tax-responsive enhancer element B67) antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~45 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• isotype: IgG
• immunogen sequence: (N-R-SP-L-P)
• NCBI accession no.: NP_001666.2
• UniProt accession no.: P18848
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer245)
• Gene Information: human ... ATF4(468)

Description

Immunogen

Peptide sequence around phosphorylation site of serine 245 (N-R-S(p)-L-P), according to the protein ATF4.

Features and Benefits

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Target description

ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable