SAB4200228

Anti-Glycogen Synthase 2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-GYS2, Anti-Glycogen synthase 2 (liver), Anti-LGS
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• form: buffered aqueous solution
• mol wt: antigen ~85 kDa
• species reactivity: rat, mouse
• concentration: ~1.0 mg/mL
• technique(s): immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded rat liver; western blot: 1.5-3 μg/mL using mouse liver extracts (S1 fraction)
• UniProt accession no.: P17625
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Gys2(232493)

Description

General description

Glycogen synthase 2 (GYS2) codes for a rate-limiting enzyme, glycogen synthase. The encoded protein is exclusively expressed in liver.

Immunogen

synthetic peptide located at the C-terminus of mouse glycogen synthase 2 (GYS2), conjugated to KLH. The corresponding sequence is highly conserved in rat GYS2 (single amino acid substitution) and in human GYS2 (84% identity).

Application

Anti-Glycogen Synthase 2 antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

Biochem/physiol Actions

Glycogen synthase 2 (GS-2) plays a vital role as a rate limiting enzyme in glycogenesis pathway in liver and adipose tissue. It acts a target gene of peroxisome proliferator-activated receptors (PPARα, PPARβ/δ and PPARγ), which are transcription factors implicated in regulation of lipid and glucose metabolism. Mutation in the gene is associated with the pathogenesis of inherited monogenic disease glycogen storage disease 0 (GSD0).

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable