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Key Documents

SAB2500444

Sigma-Aldrich

Anti-GAD2/GAD65 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-GAD65, Anti-Glutamate decarboxylase 2

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About This Item

MDL number:
MFCD03455043
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, chimpanzee, rat, canine

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q05329

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GAD2(2572)

General description

Glutamate decarboxylase 2 (GAD2) is a 65kDa protein expressed in β-cells. The gene encoding this protein is localized on human chromosome 10p12.1.

Immunogen

Peptide with sequence C-TLEDNEERMSRLSK from the internal region of the protein sequence according to NP_000809.1.

Biochem/physiol Actions

Glutamate decarboxylase 2 (GAD2) is an isoform of glutamate decarboxylase, which is involved in the synthesis of γ-aminobutyric acid (GABA). GAD2 is an auto-antigen in type I diabetes and has been shown to have a role in gastric cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

pictograms

Exclamation mark
GHS07

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Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The role of glutamate decarboxylase 65 in gastric cancer development, progression, and prognosis.
Song Y
Histopathology (2013)
Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus.
Moinuddin
IUBMB Life, 67(10) (2015)
Epigenetic signature of panic disorder: A role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation?
Katharina D
Progress in Neuro-Psychopharmacology & Biological Psychiatry (2013)
Plasma GAD65, a Marker for Early ?-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.
Ling Z
The Journal of Clinical Endocrinology and Metabolism (2015)

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