G5419

Anti-GAD1/GAD2 Antibody

mouse monoclonal, K-87

• Synonym(s): Anti-GAD 67
• MDL number: MFCD06202147
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• Product Name: Monoclonal Anti-Glutamic Acid Decarboxylase 67 (GAD67) antibody produced in mouse, clone K-87, purified antibody
• biological source: mouse
• Quality Level: 200
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: K-87, monoclonal
• mol wt: antigen 67 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:20,000 (with antigen-retrieval step); western blot: 1:500-1:20,000 using mouse brain extract
• isotype: IgG1κ
• UniProt accession no.: Q99259
• shipped in: dry ice
• storage temp.: −70°C
• target post-translational modification: unmodified
• Gene Information: human ... GAD1(2571) ; mouse ... Gad1(14415) ; rat ... Gad1(24379)

Description

General description

Glutamic Acid Decarboxylase 67 (GAD67) is encoded by the gene glutamic acid decarboxylase 1 (GAD1). GAD1 gene is located on the human chromosome at 2q31.1. GAD67 is localized in the dendrites and cell bodies.

Specificity

Reacts specifically with GAD67. Does not crossreact with GAD65.

Immunogen

This peptide does not share homology with GAD65.

synthetic peptide from mouse GAD67 (amino acids 87-106).

Application

Monoclonal Anti-Glutamic Acid Decarboxylase 67 (GAD67) antibody is suitable for use in immunoblot, western blot (at 1:500-1:20,000 dilutions using mouse brain extract) and immunohistochemistry (at 1:500-1:20,000 dilutions in mouse brain sections).

Monoclonal anti-glutamic acid decarboxylase 67 (GAD67) antibody produced in mouse has been used in:

• immunohistofluorescence
• western blotting
• immunohistochemistry.

Biochem/physiol Actions

Glutamic Acid Decarboxylase 67 (GAD67) is involved in the production of γ-amino butyric acid (GABA), a inhibitory neurotransmitter in the central nervous system (CNS). Deficiency of GAD67 leads to psychosis, schizophrenia and bipolar diseases.

Physical form

Solution in phosphate buffered saline containing 0.01% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)