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A0310

Sigma-Aldrich

Monoclonal Anti-GABA antibody produced in mouse

clone GB-69, ascites fluid

Synonym(s):

GABA Antibody - Monoclonal Anti-GABA antibody produced in mouse, Gaba Antibody Sigma, Anti-γ-Aminobutyric acid

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About This Item

MDL number:
MFCD00162297
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

GB-69, monoclonal

contains

15 mM sodium azide

species reactivity

wide range

technique(s)

dot blot: suitable
immunofluorescence: suitable
immunohistochemistry: 1:100-1:200 (Using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections.)
indirect ELISA: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Gabra1(14394)

General description

γ-Aminobutyric acid (GABA) functions as an inhibitory neurotransmitter in the central nervous system. It also functions as a neuromodulator in some peripheral tissues. Additionally, GABA is present in non-nervous tissues and regulates blood pressure, heart rate, respiration, immunomodulation, cell proliferation, protein synthesis and metabolism.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The antibody does not cross react with L-α-aminobutyric acid, L-glutamic acid, L-aspartic acid, glycine, δ-aminovaleric acid, L-threonine, L-glutamine, taurine, putrescine, L-alanine and carnosine. However, weak cross-reaction is observed with β-alanine and ε-aminocaproic acid.
Monoclonal Anti-GABA (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and a neuromodulator in certain peripheral tissues. GABA is also present in non-nervous structures.

Immunogen

GABA (γ-aminobutyric acid) conjugated to BSA

Application

Monoclonal Anti-GABA antibody produced in mouse has been used in immunohistochemistry and immunocytochemistry.

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Physical form

Supplied as ascites fluid with 15 mM sodium azide as preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Retinal neurons exhibit sustained versus transient light responses, which are thought to encode low- and high-frequency stimuli, respectively. This dichotomy has been recognized since the earliest intracellular recordings from the 1960s, but the underlying mechanisms are not yet fully understood.
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Jessen KR, et al.
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