SAB1300729

Anti-Phospho-INSR-pY1185 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-CD220 antigen, Anti-INSR, Anti-IR, Anti-Insulin receptor [Precursor]
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): dot blot: suitable; indirect ELISA: 1:1000
• NCBI accession no.: NP_000199
• UniProt accession no.: P06213
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr1185)
• Gene Information: human ... INSR(3643)

Description

General description

Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3′-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked.

Immunogen

INSR (NP_000199, 1167-1202)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable