All Photos(3)



Sodium salicylate

ReagentPlus®, ≥99.5%

Salicylic acid sodium salt, Sodium 2-hydroxybenzoate, 2-Hydroxybenzoic acid sodium salt
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

product line





>300 °C (lit.)

SMILES string




InChI key


Looking for similar products? Visit Product Comparison Guide

General description

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.


Sodium salicylate has been used:
  • to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.
  • to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.
  • to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.


500 g in poly bottle
1 kg in poly bottle
5 kg in poly drum

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC


Exclamation markHealth hazard

Signal Word


Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

208.9 °F - Pensky-Martens closed cup

Flash Point(C)

98.3 °C - Pensky-Martens closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
Niu H, et al.
BioMed Research International, 2018, 63-76 (2018)
Local application of sodium salicylate enhances auditory responses in the rat?s dorsal cortex of the inferior colliculus
Patel, Chirag R and Zhang, Huiming
Frontiers in Neurology, 5, 235-235 (2014)
Carmen S Padilla et al.
Frontiers in bioengineering and biotechnology, 8, 977-977 (2020-10-06)
Sugarcane and energy cane (Saccharum spp. hybrids) are ideal for plant-based production of recombinant proteins because their high resource-use efficiency, rapid growth and efficient photosynthesis enable extensive biomass production and protein accumulation at a cost-effective scale. Here, we aimed to
Raul Zavaliev et al.
Cell, 182(5), 1093-1108 (2020-08-19)
In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death, which is restricted by NPR1, an activator of systemic acquired resistance. However, the biochemical activities of NPR1 enabling it to promote defense and restrict cell death remain unclear.
Kui Wang et al.
Journal of medicinal chemistry, 52(20), 6402-6412 (2009-10-16)
Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service