All Photos(3)

S3007

Sigma-Aldrich

Sodium salicylate

ReagentPlus®, ≥99.5%

Synonym(s):
Salicylic acid sodium salt, Sodium 2-hydroxybenzoate, 2-Hydroxybenzoic acid sodium salt
Linear Formula:
HOC6H4COONa
CAS Number:
Molecular Weight:
160.10
Beilstein:
3732792
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

product line

ReagentPlus®

assay

≥99.5%

mp

>300 °C (lit.)

SMILES string

[Na+].Oc1ccccc1C([O-])=O

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChI key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

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General description

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.

Application

Sodium salicylate has been used:
  • to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.
  • to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.
  • to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.

Packaging

500 g in poly bottle
1 kg in poly bottle
5 kg in poly drum

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

208.9 °F - Pensky-Martens closed cup

Flash Point(C)

98.3 °C - Pensky-Martens closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
Niu H, et al.
BioMed Research International, 2018, 63-76 (2018)
Local application of sodium salicylate enhances auditory responses in the rat?s dorsal cortex of the inferior colliculus
Patel, Chirag R and Zhang, Huiming
Frontiers in Neurology, 5, 235-235 (2014)
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