R3905

Ro 27-3225 trifluoroacetate salt

≥98% (reversed phase HPLC)

• Synonym(s): Butir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoroacetate salt
• Empirical Formula (Hill Notation): C₃₉H₅₂N₁₂O₆ · xC₂HF₃O₂
• CAS Number: 1057258-86-2
• Molecular Weight: 784.91 (free base basis)
• MDL number: MFCD04112656
• UNSPSC Code: 51111800
• PubChem Substance ID: 329824026
• NACRES: NA.77

Properties

• assay: ≥98% (reversed phase HPLC)
• form: lyophilized solid
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: room temp
• SMILES string: CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)CC(N)=O
• InChI: 1S/C39H52N12O6/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44)/t29-,30-,31-,32-/m0/s1
• InChI key: NINOPZAAGJJNAR-YDPTYEFTSA-N

Description

Amino Acid Sequence

Butir-His-Phe-Arg-Trp-Sar-NH2

Biochem/physiol Actions

Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.

Features and Benefits

This compound is featured on the Melanocortin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)