All Photos(2)

P9625

Sigma-Aldrich

Phenazine methosulfate

≥90% (UV)

Synonym(s):
PMS, N-Methylphenazonium methyl sulfate, 5-Methylphenazinium methyl sulfate
Linear Formula:
C13H11N2 · CH3SO4
CAS Number:
Molecular Weight:
306.34
Beilstein:
3898869
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥90% (UV)

mp

158-160 °C (dec.) (lit.)

λ

0.01 g/L in H2O, 1 cm path

UV absorption

λ: 387.5 nm Amax: ≥90%

Mode of action

DNA synthesis | interferes
cell membrane | interferes

antibiotic activity spectrum

fungi

storage temp.

−20°C

SMILES string

COS([O-])(=O)=O.C[n+]1c2ccccc2nc3ccccc13

InChI

1S/C13H11N2.CH4O4S/c1-15-12-8-4-2-6-10(12)14-11-7-3-5-9-13(11)15;1-5-6(2,3)4/h2-9H,1H3;1H3,(H,2,3,4)/q+1;/p-1

InChI key

RXGJTUSBYWCRBK-UHFFFAOYSA-M

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General description

Phenazines are heterocyclic compounds produced as secondary metabolites by bacteria.

Application

Phenazine methosulfate is used with ascorbic acid to determine nitric oxide reductase activity.
Phenazine methosulfate has been used:
  • as a component of succinate dehydrogenase enzyme substrate solution
  • to induce superoxide radical generation in red blood cell suspensions and to study its influence on RBC deformability
  • as a component of complex II histochemistry media

Packaging

500 mg in glass bottle
1, 5, 10, 25 g in glass bottle

Biochem/physiol Actions

Phenazine m ethosulfate (PMS) acts as a good electron acceptor. PMS is reduced non-enzymatically by (nicotinamide adenine dinucleotide) NADH and (nicotinamide adenine dinucleotide phosphate) NADPH.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Assessment of oxidant susceptibility of red blood cells in various species based on cell deformability
Simmonds MJ, et al.
Biorheology, 48(5-6), 293-304 (2011)
Richard Y Wu et al.
Microbiome, 5(1), 135-135 (2017-10-12)
Prebiotics are non-digestible food ingredients that enhance the growth of certain microbes within the gut microbiota. Prebiotic consumption generates immune-modulatory effects that are traditionally thought to reflect microbial interactions within the gut. However, recent evidence suggests they may also impart...
Alba Gigante et al.
Antiviral research, 144, 216-222 (2017-06-18)
Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted to humans by Aedes mosquitoes. Since 2005, CHIKV has been spreading worldwide resulting in epidemics in Africa, the Indian Ocean islands, Asia and more recently in the Americas. CHIKV is thus considered...
Li Ling et al.
Chemosphere, 184, 417-428 (2017-06-15)
This paper applied the response surface methodology (RSM) to optimizing a novel Fe(II)/citrate/UV/PMS process in the degradation of a model micropollutant, carbamazepine (CBZ), a persistent emerging contaminant frequently detected in surface water and groundwater. The experimental conditions in terms of...
Duong Luong et al.
Materials science & engineering. C, Materials for biological applications, 103, 109759-109759 (2019-07-28)
Transition metals (TM) are essential microelements with various biological functions demanded in tissue regeneration applications. Little is known about therapeutic potential of TM within soft hydrogel biomaterials. The soluble divalent TM, such as Zn, Cu, Mn and Co, were stably...

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