P6149

Progesterone

γ-irradiated, BioXtra, suitable for cell culture

• Synonym(s): 4-Pregnene-3,20-dione
• Empirical Formula (Hill Notation): C₂₁H₃₀O₂
• CAS Number: 57-83-0
• Molecular Weight: 314.46
• Beilstein: 1915950
• EC Number: 200-350-6
• MDL number: MFCD00003658
• PubChem Substance ID: 24898649
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• description: synthesized from materials derived from plant source
• sterility: γ-irradiated
• product line: BioXtra
• Assay: ≥99%
• form: powder
• potency: 0.1-20 ng/mL
• technique(s): cell culture | mammalian: suitable
• mp: 128-132 °C (lit.)
• solubility: chloroform: 50 mg/mL, clear, colorless to light yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• InChI key: RJKFOVLPORLFTN-LEKSSAKUSA-N
• Gene Information: human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

Description

Application

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Other Notes

Steroid hormone produced by the corpus luteum.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 20 μg/ml stock solution, add 1 ml absolute ethanol, gently swirl to dissolve, add 49 ml sterile medium.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H351 - H360FD - H362
• Precautionary Statements: P202 - P260 - P263 - P264 - P270 - P308 + P313
• Hazard Classifications: Carc. 2 - Lact. - Repr. 1A
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves