P0359

Palmitoylethanolamide

• Synonym(s): N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol
• Empirical Formula (Hill Notation): C₁₈H₃₇NO₂
• CAS Number: 544-31-0
• Molecular Weight: 299.49
• EC Number: 208-867-9
• MDL number: MFCD00020562
• PubChem Substance ID: 24278619
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCCC(=O)NCCO
• InChI: 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
• InChI key: HXYVTAGFYLMHSO-UHFFFAOYSA-N
• Gene Information: human ... CNR1(1268) , CNR2(1269) ; rat ... Faah(29347)

Description

Application

Palmitoylethanolamide has been used as a reference standard in mass spectrometry (MS/MS).

Biochem/physiol Actions

Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. It is found in soybeans, egg yolk, and many other food sources. PEA is an endogenous cannabinoid receptor agonist. It is a peroxisome proliferator-activated receptor α (PPAR-α) ligand. PEA possesses anti-inflammatory, anti-allergic, neuroprotective, and analgesic activities. It belongs to the class of lipid mediators and the N-acylethanolamine family. PEA blocks the release of pro-inflammatory mediators from activated mast cells and prevents the recruitment of activated mast cells at the site of nerve injury.

Linkage

Structural analog of anandamide.

Safety Information

• Pictograms: GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H315 - H318 - H411
• Precautionary Statements: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves